Myeloid Leukemia: Methods and Protocols (Methods in Molecular Medicine)
Publisher: Humana Press
Number Of Pages: 320
Publication Date: 2005-11-15
Sales Rank: 2492177
ISBN / ASIN: 1588294854
EAN: 9781588294852
Binding: Hardcover
Manufacturer: Humana Press
Studio: Humana Press
A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
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